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Our Pipeline
Skyhawk develops a broad portfolio of small molecule RNA-modifying drug candidates that have the potential to improve the lives of patients by directly addressing the causes of disease.
Our wholly-owned pipeline includes programs across neurodegenerative, oncology, neuromuscular, fibrosis and other disease types. Many of our programs are against targets formerly considered “undruggable” for traditional protein-targeting mechanisms.
Huntington's Disease
SKY-0515
HTT
Small molecule splicing modulator
Phase 3
Discovery
Preclinical
Phase 1
Phase 2
Target
Platform
Product Candidate
Multiple-Myeloma/
Non-Hodgkins
Lymphoma
SKY-1214
FANCL/ FANCI
Small molecule splicing modulator
Spinocerebellar Ataxia Type 3
SKY-1300
ATXN3
Small molecule splicing modulator
HRD Solid
Tumors
SKY-1800
Small molecule splicing modulator
Undisclosed
Frontotemporal Dementia
SKY-1500
MAPTe10
Small molecule splicing modulator
Solid Tumors
SKY-1400
Undisclosed
Small molecule splicing modulator
Fibrosis
SKY-1700
Undisclosed
Small molecule splicing modulator
Indication
Internal/
Partner
Oncology Assets
Neurology Assets
Fibrosis Assets
Partnered Pipeline
Our confidential partnered pipeline with major Pharma includes over a dozen preclinical programs
across neurodegenerative, oncology, neuromuscular, rare and other disease types.
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